Publications

2022

• Ozmadenci D, Shankara Narayanan JS, Andrew J, Ojalill M., Barrie AM, Jiang S, Iyer S, Chen XL, Rose M, Estrada V, Molinolo A, Bertotto T, Mikulski Z, McHale MC, White RR, Connolly DC, Pachter JA, Kuchroo VK, Stupack DG, and Schlaepfer DD (2022). Tumor FAK Orchestrates Immunosuppression in Ovarian Cancer via the CD155/TIGIT axis. Proceedings of the National Academy of Science, USA 119 (17) e2117065119 [PMCID: PMC9169934]

• Jeong K, Murphy JM, Kim JH, Campbell PM, Park H, Rodriguez YAR, Choi CS, Kim JS, Park S, Kim HJ, Scammell JG, Weber DS, Honkanen RE, Schlaepfer DD, Ahn EE, Lim SS (2021). FAK activation promotes SMC dedifferentiation via increased DNA methylation in contractile genes. Circulation Research 2021 Dec 3;129(12):e215-e233. [PMCID: PMC8639767]

• Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O'Neill EB, Eyckmans J, Chen CS, Fu J, Schlaepfer DD, García AJ (2021). Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nature Communications Apr 21;12(1):2359. [PMCID: PMC8060400]

• Lee SG, Kim JS, Kim HJ, Schlaepfer DD, Kim IS, Nam JO (2021). Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI. Science Reports 2021 May 6;11(1):9644. [PMCID: PMC8102489]

• Delaney JR, Patel CB, Bapat J, Jones CM, Ramos-Zapatero M, Ortell KK, Tanios R, Haghighiabyaneh M, Axelrod J, DeStefano JW, Tancioni I, Schlaepfer DD, Harismendy O, La Spada AR, and Stupack DG (2020). Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. PLoS Genetics 2020 Jan 10;16(1):e1008558. doi: 10.1371/journal.pgen.1008558. [PMCID: PMC6953790]

2019

• CJ Díaz-Osterman, D Ozmadenci, EG Kleinschmidt, KN Taylor, AM Barrie, S Jiang, LM Bean, FJ Sulzmaier, C Jean, I Tancioni, K Anderson, S Uryu, EA Cordasco, J Li, XL Chen, G Fu, M Ojalill, P Rappu, J Heino, AM Mark, G Xu, KM Fisch, VN Kolev, DT Weaver, JA Pachter, B Győrffy, MT McHale, DC Connolly, A Molinolo, DG Stupack and DD Schlaepfer (2019). FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. eLife 8:e47327 DOI: 10.7554/eLife.47327. PMID: 31478830

• EG Kleinschmidt, NLG Miller, D Ozmadenci, I Tancioni, CJ Díaz-Osterman, AB Barrie, KN Taylor, A Ye, S Jiang, DC Connolly, DG Stupack and DD Schlaepfer (2019). Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene 38(36):6323-6337. PMID: 31308489

• K Jeong, JH Kim, JM Murphy, H Park, SJ Kim, Y Rodriguez, H Kong, C Choi, J-L Guan, JM Taylor, TM Lincoln, WT Gerthoffer, JS Kim, EY Ahn, DD Schlaepfer and ST Lim (2019). Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcription. Circulation Research 125(2):152-166. PMID: 31096851

• X Feng, N Arang, DC Rigiracciolo, JS Lee, H Yeerna, Z Wang, S Lubrano, A Kishore, JA Pachter, GM Konig, M Maggiolini, E Kostenis, DD Schlaepfer, P Tamayo, Q Chen, E Ruppin and JS Gutkind (2019). A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell 35: 3457-472. PMID: 30773340

2018

• KN Taylor and DD Schlaepfer (2018). Adaptive Resistance to Chemotherapy, A Multi-FAK-torial linkage. Molecular Cancer Therapeutics Apr;17(4):719-723. PMCID: PMC6538033

2017

• JR Delaney, CB Patel, KM Willis, M Haghighiabyaneh, J Axelrod, I Tancioni, D Lu, J Bapat, S Young, O Cadassou, A Bartakova, P Sheth, C Haft, S Hui, C Saenz, DD Schlaepfer, O Harismendy and DG Stupack (2017). Haploinsufficiency networks identify targetable pattern of allelic deficiency in low mutation ovarian cancer. Nature Communications 8:14423. PMID: 28198375

• EG Kleinschmidt and DD Schlaepfer (2017). Focal adhesion kinase signaling in unexpected places. Current Opinion in Cell Biology 45: 24-30. PMID: 28213315

2016

• A Yurdagul Jr, FJ Sulzmaier, XL Chen, CB Pattillo, DD Schlaepfer and AW Orr (2016). Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression. Journal of Cell Science 129, 1580-1591. PMID: 26906414

• H Laklai, YA Miroshnikova, MW Pickup, EA Collisson, GE Kim, AS Barrett, RC Hill, JN Lakins, DD Schlaepfer, JK Mouw, VS LeBleu, N Roy, SV Novitsky, JS Johansen, V Poli, R Kalluri, CA Iacobuzio-Donahue, LD Wood, M Hebrok, K Hansen, HL Moses and VM Weaver (2016). Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine 5: 497-505. PMID: 27089513

2015

• I Tancioni, NLG Miller, S Uryu, C Lawson, C Jean, XL Chen, EG Kleinschmidt and DD Schlaepfer (2015). FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Research 17:47 PMCID: PMC4407832

• M. Masià-Balague, I Izquierdo, G Garrido, A Cordomí, L Perez, NLG Miller, DD Schlaepfer, V Gigoux and AM Aragay (2015). Gastrin-stimulated Galpha13 activation of Rgnef (ArhGEF28) in DLD-1 colon carcinoma cells. Journal of Biological Chemistry 290:15197-209. PMCID: PMC4463461

• SA Young, KE McCabe, A Bartakova, JR Delaney, DP Pizzo, RO Newbury, JA Varner, DD Schlaepfer and DG Stupack (2015). Integrin α4 enhances metastasis and may be associated with poor prognosis in MYCN-low neuroblastoma. PLoS ONE 10(5): e0120815. PMCID: PMC4431816

• C Gao, G Chen, SH Kuan, DH Zhang, DD Schlaepfer and J Hu (2015). FAK/PYK2 promotes the Wnt/b-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. eLife; 10.7554/eLife.10072. PMCID: PMC4558782

• JR Delaney, C Patel, KE McCabe, D Lu, MA Davis, I Tancioni, T Khattar, A Bartakova, C Haft, DD Schlaepfer and DG Stupack (2015). A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Oncotarget 6: 31104-31118. PMID: 26418751

2014

• C Jean, XL Chen, JO Nam, S Uryu, I Tancioni, C Lawson, KK Ward, CT Walsh, NLG Miller, M Ghassemian, P Turowski, E Dejana, DA Cheresh and DD Schlaepfer, DD (2014). Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. Journal of Cell Biology 204: 247-263. PMCID: PMC3897185

• I Tancioni, S Uryu, FJ Sulzmaier, NR Shah, C Lawson, NLG Miller, C Jean, XL Chen, KK Ward and DD Schlaepfer (2014). FAK inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. Molecular Cancer Therapeutics 13: 2050-61. PMCID: PMC4126870

• NR Shah, I Tancioni, KK Ward, C Lawson, XL Chen, C Jean, FJ Sulzmaier, S Uryu, NLG Miller, DC Connolly and DD Schlaepfer (2014). Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer. Gynecologic Oncology 134: 104-11 PMCID: PMC4065804

• NLG Miller, EG Klenischmidt and DD Schlaepfer (2014). RhoGEFs in cell motility: Novel links between Rgnef and focal adhesion kinase. Current Molecular Medicine 2: 221-234. PMCID: PMC4075329

• FJ Sulzmaier, C Jean and DD Schlaepfer (2014). FAK in cancer: mechanistic findings and clinical applications. Nature Reviews Cancer 14: 598-610. PMCID: PMC4365862

• SY Cheng, G Sun, DD Schlaepfer and CJ Pallen (2014). Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex. Molecular and Cellular Biology 34: 348-61. PMCID: PMC3911518

2013

• KK Ward, I Tancioni, C Lawson, NLG Miller, C Jean, XL Chen, S Uryu, J Kim, DG Stupack, SC Plaxe and DD Schlaepfer (2013). Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clinical and Experimental Metastasis 5: 579-94. PMCID: PMC3622195

• R Graf, S Barbero, N Keller, XL Chen, S Uryu, DD Schlaepfer and DG Stupack, DG (2013). Src inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adhesion and Migration 7: 362-369. PMCID: PMC3739813

• NLG Miller, C Lawson, S Uryu, EG Klenischmidt and DD Schlaepfer, DD (2013). A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. Journal of Cell Science 126: 5074–5085. PMCID: PMC3820247

• C Lawson and DD Schlaepfer (2013). pHocal adhesion kinase regulation is on a FERM foundation. Journal of Cell Biology 202: 833-836. PMCID: PMC3776349

2012

• XL Chen, JO Nam, C Jean, C Lawson, CT Walsh, E Goka, ST Lim, A Tomar, I Tanjoni, S Uryu, JL Guan, LM Acevedo, SM Weis, DA Cheresh, and DD Schlaepfer (2012). VEGF-induced vascular permeability is mediated by FAK. Developmental Cell 22: 146-157. PMCID: PMC3266538

• M Huang, S Anand, EA Murphy, JS Desgrosellier, DG Stupack, SJ Shattil, DD Schlaepfer, DD and DA Cheresh (2012). EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene 31: 2783-2793. PMCID: PMC3711644

• C Lawson, ST Lim, S Uryu, XL Chen, DA Calderwood and DD Schlaepfer, DD (2012). FAK promotes recruitment of talin to nascent adhesions to control cell motility. Journal of Cell Biology 196: 223-232. PMCID: PMC3265949

• SK Lau, DJ Shields, EA Murphy, JS Desgrosellier, S Anad, M Huang, ST Lim, DD Schlaepfer and DA Cheresh (2012). EGFR-mediated carcinoma cell metastasis mediated by integrin avb5 depends on activation of c-Src and cleavage of MUC1. PLosOne 7(5): e36753. PMCID: PMC3346745

• NLG Miller, C Lawson, XL Chen, ST Lim and DD Schlaepfer (2012). Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell migration downstream of integrins PLosOne 7(5): e36753. PMCID: PMC3359313

• ST Lim, NLG Miller, XL Chen, I Tancioni, CT Walsh, C Lawson, S Uryu, SM Weis, DA Cheresh and DD Schlaepfer (2012). Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. Journal of Cell Biology 197: 907-919. PMCID: PMC3384409

• A Tomar, C Lawson, M Ghassemian and DD Schlaepfer (2012). Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLosOne 7: e44041. PMCID: PMC3430618

• O Jung, S Choi, SB Jang, SA Lee, ST Lim, YJ Choi, HJ Kim, DH Kim, TK Kwak, H Kim, M Kang, MS Lee, SY Park, J Ryu, D Jeong, HK Cheong, HJ Kim, KH Park, BJ Lee, DD Schlaepfer and JW Lee (2012). Tetraspanan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. Journal of Cell Science 125: 5960-73. PMCID: PMC4074290

• C Lawson and DD Schlaepfer (2012). Integrin adhesions: Who's on first? What's on second? Connections between FAK and talin. Cell Adhesion & Migration 6: 302-306. PMCID: PMC3478250

  2011

  • HG Yu, JO Nam, NLG Miller, I Tanjoni, CT Walsh, L Shi, L Kim, XL Chen, A Tomar, ST Lim and DD Schlaepfer (2011). p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Research 71: 360-70. PMCID: PMC3064514

  • J Seong, M Ouyang, T Kim, J Sun, PC Wen, S Lu, Y Zhuo, NM Llewellyn, DD Schlaepfer, JL Guan, S Chien and Y Wang (2011). Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nature Communications 2: 406. PMCID: PMC3373894

  • XY Li, X Zhou, RG Rowe, Y Hu, DD Schlaepfer, D Ilic, G Dressler, A Park, JL Guan and SJ Weiss (2011). Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. Journal of Cell Biology 195: 729-38. PMCID: PMC3257570

2010

• ST Lim, NLG Miller, JO Nam, XL Chen, Y Lim and DD Schlaepfer (2010). Pyk2 inhibition of p53 as an adaptive and intrinsic switch promoting cell proliferation and survival. Journal of Biological Chemistry 285: 1743-1753. PMCID: PMC2804332

• I Tanjoni, CT Walsh, S Uryu, A Tomar, JO Nam, A Mielgo, ST Lim, C Liang, M Koenig, N Patel, C Kwok, G McMahon, DG Stupack and DD Schlaepfer (2010). PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biology and Therapy 9: 764-777. PMCID: PMC2933317

• CT Walsh, I Tanjoni, S Uryu, A Tomar, JO Nam, H Luo, A Phillips, N Patel, C Kwok, G McMahon, DG Stupack, and DD Schlaepfer (2010). Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical tumor models. Cancer Biology and Therapy 9: 778-790. PMCID: PMC2933309

• AM Pasapera, I Schneider, E Rericha, DD Schlaepfer and Waterman (2010). Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. Journal of Cell Biology 188: 877-890. PMCID: PMC2845065

• ST Lim, XL Chen, A Tomar, NLG Miller, J Yoo and DD Schlaepfer (2010). Knockin mutation reveals an essential role for FAK activity in blood vessel morphogenesis, cell motility-polarity, but not cell proliferation. Journal of Biological Chemistry 285: 21526-21536. PMCID: PMC2898428

• A Tomar and DD Schlaepfer (2010). A PAK-Activated Linker for EGFR and FAK. Developmental Cell 18: 170-172. PMCID: PMC3081666

2009

• J Ricono, M Huang, L Barnes, S Lau, SM Weis, DD Schlaepfer, SK Hanks and DA Cheresh (2009) Specific crosstalk between EGFR and integrin avb5 promotes carcinoma cell invasion and metastasis. Cancer Research 69: 1383-1391. PMCID: PMC2741736

• J Vomaske, RM Melnychuk, PP Smith, J Powell, L Hall, V Defilippis, K Früh, M Smit, DD Schlaepfer, JA Nelson and DN Streblow (2009). Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathogen 5: e1000304. PMCID: PMC2637432

• S Barbero, A Mielgo, V Torres,T Teitz, DJ Shields, D Mikolon, M Bogoyo, D Barila, JM Lahti, DD Schlaepfer and DG Stupack (2009). Caspase 8 promotes metastasis. Cancer Research. 69: 3755-3763. PMCID: PMC2684981

• A Tomar, ST Lim, Y Lim and DD Schlaepfer D.D. (2009). A FAK, p120RasGAP, and p190RhoGAP complex regulates polarity in migrating cells. Journal of Cell Science 122: 1852-1862. PMCID: PMC2684836

• A Tomar and DD Schlaepfer (2009). Focal adhesion kinase: Switching between GAPs and GEFs in the control of cell motility. Current Opinion in Cell Biology 21: 673-683. PMCID: PMC2754589

2008

• ST Lim, XL Chen DA Hanson, Y Lim, TT Vo, K Howerton, P Dazin, SJ Fisher, DD Schlaepfer* and D Ilic (2008). Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Molecular Cell, 29: 9-22. PMCID: PMC2234035 *Corresponding author.

• Lim, Y., Lim, S.-T., Tomar, A., Gardel, M., Bernard-Trifilo, J.A., Chen, X.L., Uryu, S., Canete-Soler, R., Zhai, J., Lin, H., Schlaepfer, W.W., Nalbant, P., Bokoch, G.M., Ilic, D., Waterman-Storer, C., and Schlaepfer, D.D. (2008). Pyk2 and FAK connections to p190RhoGEF regulate RhoA activity, focal adhesion formation, and cell motility. Journal of Cell Biology 180: 187-203. PMCID: PMC2213606

• SM Weis, ST Lim, KM Lutu-Fuga, L Barnes, XL Chen, JR Göthert, TL Shen, JL Guan, DD Schlaepfer and DA Cheresh (2008). Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. Journal of Cell Biology 181: 43-50. PMCID: PMC2287283

• V Ossovskaya, ST Lim, N Ota, DD Schlaepfer and D Ilic (2008). FAK nuclear export signals sequences. FEBS Letters 582: 2402-6. PMCID: PMC2547126

• K Howerton, DD Schlaepfer and D Ilic (2008). Establishment of cell lines from mouse embryos with early embryonic lethality. Cell Communication and Adhesion 15: 379-383. PMCID: PMC3057554

• ST Lim, D Mikolon, DG Stupack and DD Schlaepfer (2008). FERM control of FAK function: Implications for cancer therapy. Cell Cycle 7: 2306-2314. PMCID: PMC2574722

• L Wu, JA Bernard-Trifilo, Y Lim, ST Lim, SK Mitra, S Uryu, M Chen, CJ Pallen, NKV Cheung, D Mikolon, A Mielgo, DG Stupack and DD Schlaepfer (2008). Distinct FAK-Src activation events promote a5b1- and a4b1-stimulated neuroblastoma cell motility. Oncogene 27: 1439-1448. PMCID: PMC2593630