Publications

Mellon Lab Publications (since 2004)

Lavalle, S. N., Chou, T., Hernandez, J., Naing, N. C. P., He, M. Y., Tonsfeldt, K. J., and Mellon, P. L. (2022). Deletion of the Homeodomain Gene SIX 3 from Kisspeptin Neurons Causes Subfertility in Female Mice. Molecular and Cellular Endocrinology 456(4), 111577. PMID: 35121076.

Meadows, J. D., Breuer, J. A., Lavalle, S. N., Hirschenberger, M. R., Patel, M. M., Nguyen, D., Kim, A., Cassin, J., Gorman, M. R., Welsh, D. K., Mellon, P. L., Hoffmann, H. M. (2022). Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice. Molecular Metabolism 57(3), 101431. PMID: 34974160

Tonsfeldt, K. J., Mellon, P. L., and Hoffmann, H. M. (2022). Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge. Endocrinology 163 (2), 1-10. bqab268. (Review Article). PMID: 34967900; PMC8782605

Ho, E. V., Shi, C., Cassin, J., He, M. Y., Nguyen, R. D., Ryan, G. E., Tonsfeldt, K. J., Mellon, P. L. (2021). Reproductive Deficits Induced by Prenatal Anti-Mullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells. Endocrinology 162(12), 1-23. PMID: 34529765. PMC8507963

Hoffmann, H. M., Meadows, J. D., Breuer, J. A., Yaw, A. M., Nguyen, D., Tonsfeldt, K. J., Chin, A. Y., Devries, B. M., Trang, C., Oosterhouse, H. J., Lee, J. S., Doser, J. W., Gorman, M. J., Welsh, D. K., Mellon, P. L. (2021). The Transcription Factors SIX3 and VAX1 are Required for Suprachiasmatic Nucleus Circadian Output and Fertility in Female Mice. Journal of Neuroscience Research 99(10), 2625-2645. PMID: 34212416. PMC8577618.

Lavalle, S. N., Chou, T., Hernandez, J., Naing, N. C. P., Tonsfeldt, K. J., Hoffmann, H. M., Mellon, P. L. (2021). Kiss1 is Differentially Regulated in Male and Female Mice by the Homeodomain Transcription Factor VAX1. Molecular Cellular Endocrinology 534(8), 111358. PMID: 34098016. PMC8319105.

Bohaczuk, S. C., Cassin, J., Slaiwa, T. I., Thackray, V. G., Mellon, P. L. (2021). Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB. Endocrinology 162(7), 1-15. PMID: 33824966. PMC8157479.

Ryan, G. E. , Bohaczuk, S. C., Cassin, J., Witham, E. A., Shojaei, S., Ho, E. V., Thackray, V. G., Mellon, P. L. (2021). Androgen Receptor Positively Regulates Gonadotropin-releasing Hormone Receptor in Pituitary Gonadotropes. Molecular and Cellular Endocrinology 530(6), 111286. PMID: 33872733. PMC 8177864

Schoeller E. L.,* Tonsfeldt, K. J.,* Sinkovich, M., Shi, R., Mellon, P. L. (2021). Growth Hormone Pulses and Liver Gene Expression are Differentially Regulated by the Circadian Clock Gene Bmal1. Endocrinology 162(4), 1-16. PMID: 33539533. PMC7901660. *equivalent contributions

Bohaczuk, S. C., Thackray V. G., Shen, J., Skowronska-Krawczyk, D., Mellon, P. L. (2020). FSHβ Transcription is Regulated by a Novel 5’ Distal Enhancer with a Fertility-Associated Single Nucleotide Polymorphism. Endocrinology 162(1), 1-12. PMID: 33009549, PMC784614

Coré, N., Erni, A., Hoffmann, H. M., Mellon, P. L., Saurin, A. J., Béclin, C., and Cremer, H. (2020). Stem Cell Regionalization During Olfactory Bulb Neurogenesis Depends on Regulatory Interactions between Vax1 and Pax6. eLife 9, e58215. PMID: 32762844; PMC7440913

Nicholas, D. A., Knight, V. S., Tonsfeldt, K. J., Terasaka, T., Molinar-Inglis, O., Stephens, S. B. Z., Trejo, J., Kauffman, A. S., Mellon, P. L., Lawson, M. A. (2020). GLUT1-mediated Glycolysis Supports GnRH-induced Secretion of Luteinizing Hormone from Female Gonadotropes. Scientific Reports, 10, 13063. PMID: 32747664; PMC 7400764

Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B. E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., Zhang, X., Meng, F., Li, H., Zhang, X., Xu, R., Li, D., Rosenfeld, M. G., Mellon, P. L., Adams, J. A., Liu, M.-F., Fu, X.-D. (2020). Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. Cell 180(6), 1212-1227. PMID: 3216915; PMC7190278

Pandolfi, E. C. , Breuer, J. A., Huu, V. A. N., Talluri, T., Nguyen, D., Lee, J. S., Hu, R., Bharti, K., Skowronska-Krawczyk , D., Gorman, M. R., Mellon, P. L., Hoffmann, H. M. (2019). The Homeodomain Transcription Factors Vax1 and Six6 are Required for SCN Development and Function. Molecular Neurobiology 57(2), 1217-1232. PMID:31705443; PMC7035166

Pandolfi, E. C., Tonsfeldt, K. J., Hoffmann, H. M., and Mellon, P. L. (2019). Deletion of the Homeodomain Protein Six6 from GnRH Neurons Decreases GnRH Gene Expression Resulting in Infertility. Endocrinology, 160, 2151-2164 PMID:31211355; PMC6821215

Ruf-Zamojski, F., Ge, Y., Pincas, H., Shan, J., Song, Y., Hines, N., Kelley, K., Montagna, C., Nair, P., Toufaily, C., Bernard, D. J., Mellon, P. L., Nair, V., Turgeon, J. L., and Sealfon, S. C. (2019). Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines: Identification of Two LβT2 Lines. Journal of the Endocrine Society 3, 902-920. PMID: 31020055; PMC6469952

Hoffmann, H. M.,* Larder, R.,* Lee, J. S., Hu, R. J., Trang, C., Devries, B. M., Clark, D. D., and Mellon, P. L. (2019). Differential CRE expression in Lhrh-cre and Gnrh-cre alleles and the impact on fertility in Otx2-flox mice. Neuroendocrinology, 108, 328-342. PMID:30739114 ; PMC6753941 *equivalent contributions

Tonsfeldt, K. J., Schoeller, E. L., Brusman, L. E., Cui, L. J., Lee, J., Mellon, P. L. (2019). The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. Journal of the Endocrine Society 3, 716-733. PMID: 30906911; PMC6425515

Hoffmann, H. M.,* Pandolfi, E. C.,* Larder, R.,* Mellon, P. L. (2018). Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology , in press. *Co-first authors. (Review Article). PMID: 30261489; PMC6437011

Pandolfi, E. C., Hoffmann, H. M., Schoeller, E. L., Gorman, M. R., and Mellon, P. L. (2018). Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior through Disrupted Olfactory Development, and Impairs Female Fertility through Disrupted GnRH Neuron Migration. Molecular Neurobiology 55, 8709-8727. PMID: 29589282; PMC6156938

Que, X., Hung, M.-Y., Yeang, C., Gonen, A., Prohaska, T., Sun, X., Diehl, C., Määttä, A., Gaddis, D. E., Bowden, K., Pattison, J., MacDonald, J. G., Ylä-Herttuala, S., Mellon, P. L., Hedrick, C. C., Ley, K., Miller, Y. I., Glass, C. K., Peterson, K. L., Binder, C. J., Tsimikas, S., Witztum, J. L. (2018). Oxidized Phospholipids are Proinflammatory and Proatherogenic in Hypercholesterolemic Mice. Nature 558, 301-306; PMID: 29875409; PMC6033669

Ryan, G. E., Malik, S., Mellon, P. L. (2018). Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-induced Mouse Model of PCOS. Endocrinology 159, 1734-1747. PMID: 29471436; PMC6097580

Hoffmann, H. M., Gong, P., Tanrazian, A., Mellon, P. L. (2017). Transcriptional Interaction Between cFOS and the Homeodomain-binding Transcription Factor VAX1 on the GnRH Promoter Controls Gnrh1 Expression Levels in a GnRH Neuron Maturation Specific Manner. Molecular and Cellular Endocrinology 461, 143-154 . PMID: 28890143; PMC5756504

Xie, H., Hoffmann, H. M., Iyer, A. K., Brayman, M. J., Ngo , C., Sunshine, M. J., and Mellon, P. L. (2017). Chromatin Status and Transcription Factor Binding to Gonadotropin Promoters in Gonadotrope Cell Lines . Reproductive Biology and Endocrinology 15, 86 . PMID: 29065928; PMC5655979

Schoeller, E. L., Clark, D. D., Dey, S., Cao, N. V., Semaan, S. J., Chao, L. W., Kauffman, A. S., Stowers, L., Mellon, P. L. (2016). Bmal is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology 157, 4914-4929. PMID: 27704948, PMC5133342

Huang, P. P., Brusman, L. E., Iyer, A. K., Webster, N. J. G., Mellon, P. L. (2016). A Novel Gonadotropin-Releasing Hormone 1 ( GnRH1) Enhancer-Derived Noncoding RNA Regulates GnRH1 Gene Expression in GnRH Cell Models. PlosOne 11(7):e0158597 . PMID: 27389022, PMC4936741

Hoffmann, H. M., Trang, C., Gong, P., Kimura, I., Pandolfi, E. C., and Mellon, P. L. (2016). Deletion of Vax1 from GnRH Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. Journal of Neuroscience 36, 3506-3518 . PMID: 27013679 PMC4804008

Skowronska-Krawczyk, D., Zhao, L., Zhu, J., Weinreb, R. N., Cao, G., Luo, J., Flagg, K., Patel, S., Wen, C., Krupa, M., Luo, H., Ouyang, H., Lin, D., Wang, W., Li, G., Xu, Y., Li, O., Chung, C., Yeh, E., Jafari, M., Ai, M., Zhong, Z., Shi, W., Zheng, L., Krawczyk, M., Chen, D., Shi, C., Zin, C., Zhu, J., Mellon, P. L., Gao, W., Abagyan, R., Zhang, L., Sun, X., Zhong, S., Zhuo, Y., Rosenfeld, M. G., Liu, Y., Zhang, K. (2015). P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Molecular Cell 59, 931-940. PMID: 26365380, PMC4648709

Kauffman, A. S., Thackray, V. G., Ryan, G. E., Tolson, K. P., Glidewell-Kenney, C. A., Seeman, S. J., Poling, M. C., Iwata, N., Breen, K. M., Duleba, A. J., Stener-Victorin, E., Shimasaki, S., Webster, N. J., and Mellon, P. L. (2015). A Novel Letrozole Mouse Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biology of Reproduction 93(3):69, 1-12. PMID: 26203175 , PMC 4710190

Stephens, S. B, Tolson, K. P., Rouse, M. L., Poling, M. C., Hashimoto-Partyka, M. K., Mellon, P. L., Kauffman, A. S. (2015). Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology 156, 3091–3097. PMID: 26076042, PMC4541622

Xie, H., Hoffmann,* H. M., Meadows,* J. D., Mayo, S. L., Trang, C., Leming, S., Maruggi, C., Davis, S. W., Larder, R., and Mellon, P. L. (2015). Homeodomain Proteins Six6 and Six3 Regulate Gonadotrope-specific Genes During Pituitary Development. Molecular Endocrinology 29, 842-855. *Co-second author. PMID: 25915183, PMC4447639

Ahow,* M., Min,* L., Pampillo, M., Nash, C., Wen, J., Soltis, K., Carroll, R. S., Glidewell-Kenney, C. A., Mellon, P. L., Bhattacharya, M., Tobet, S. A., Kaiser,# U. B., Babwah,# A. V. (2014). KISS1R Signals Independently of Gαq/11 and Triggers LH Secretion Via the β-arrestin Pathway in the Male Mouse. Endocrinology 155, 4433-4446. *Co-first author; #Co-Senior author. PMID: 25105693, PMC4197989

Roybal, L. L., Hambarchyan, A., Meadows, J. D., Barakat, N. H., Pepa, P. A., Breen, K. M., Mellon, P. L., and Coss, D. (2014). Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Molecular Endocrinology 28, 1640-1655. PMID: 25105693, PMC4179627

Hoffmann, H. M., Tamrazian, A., Xie, H., Pérez-Millán, M. I., Kauffman, A. S., and Mellon, P. L. (2014). Heterozygous Deletion of Ventral Anterior Homeobox (Vax1) Causes Subfertility in Mice. Endocrinology 155, 4043–4053. PMID 25060364, PMC4164932

Glidewell-Kenney, C. A., Trang, C., Shao, P. P., Guteirrez-Reed, N., Uzo-Okereke, A. M., Coss, D., Mellon, P.L. (2014). Neurokinin B Induces c-fos Transcription via Protein Kinase C and Activation 1 of Serum Response Factor and Elk-1 in Immortalized GnRH Neurons. Molecular Endocrinology 27, 437-454. PMID 23393128, PMC3589675

Witham, E. A., Meadows, J. D., Hoffmann, H. M., Shojaei, S., Coss, D., Kauffman, A. S., and Mellon, P. L. (2013). Kisspeptin Regulates Gonadotropin Genes Via Immediate Early Gene Induction in Pituitary Gonadotropes. Molecular Endocrinology 27, 1283-1294. PMID 23770611, PMC3725344

Larder, R., Kimura, I., Meadows, J. D., Clark, D. D., Mayo, S., and Mellon, P. L. (2013). Gene Dosage of Otx2 is Important for Fertility in Male Mice. Molecular Cellular Endocrinology 377, 16-22. PMID 23811236, PMC3771655

Glidewell-Kenney, C. A., Shao, P. P., Iyer, A. K., Grove, A. M. H., Meadows, J. D., and Mellon, P. L. (2013). Neurokinin B Causes Acute GnRH Secretion and Long-term Repression of GnRH Transcription in GT1-7 GnRH Neurons. Molecular Endocrinology 27, 437-454. PMID 23393128, PMC3589675