Publications

An optimized fractionation method reveals insulin-induced membrane surface localization of GLUT1 to increase glycolysis in LβT2 cells. (2025) O. Molinar-Inglis, K. Wiggins, A. Varma, Z. Del Mundo, J.M. Adame, A. Cozzo, O. Muñoz, U.-V. Le, D. Trinh, A. C. Garcia, M. Cisneros-Aguirre, M.L. Gonzalez Ramirez, J. Keyes, J. Zhang, M. A. Lawson, J. Trejo, D. A. Nicholas. Molecular and Cellular Endocrinology (595) 112405. DOI: https://doi.org/10.1016/j.mce.2024.112405

Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape (2024) C. Garcia, L. M. Velez, N. Ujagar, Z. Del Mundo, T. Nguyen, C. Fox, A. Mark, K. M. Fisch, M. A. Lawson, A. J. Duleba, M. M. Seldin, and D. A. Nicholas. Frontiers in Endocrinology, (14), 1279878. DOI: https://doi.org/10.3389/fendo.2023.1279878

The Culture and Justice Quorum at University of California, San Diego: A Departmental Approach to Dismantling Structural Racism. (2023). Ha, D., Ghebrendrias, S.; Meadows, A., LaCoursiere, D. Y., Lewis, A., Lawson, M., Morales, Mi.,Gyamfi-Bannerman, C., Brubaker, L. Academic Medicine :e005200, DOI: https://doi.org/10.1097/ACM.0000000000005200

Introduction to Endocrinology: The Hypothalamic-Pituitary Axis. (2023). Nicholas, D.A. and Lawson, M.A. Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 14hEd., L.L. Brunton, B.C. Knollman, eds. McGraw Hill ISBN 9781264258079. https://accessmedicine.mhmedical.com

aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2–mediated SphK1-S1PR1-Akt signaling axis. (2021). Molinar-Inglis, O., C. A. Birch, D. A. Nicholas, L. Orduña-Castillo, M. Cisneros-Aguirre, A. Patwardhan, B. Chen, N. J. Grimsey, L.J. Coronel, H. Lin, P. K. Gomez Menzies, M.A. Lawson, H. H. Patel, and JoAnn Trejo. Proc. Natl. Acad. Sci. USA. 188, 49 (e2106623118). DOI: https://doi.org/10.1073/pnas.2106623118

Androgen suppresses in vivo and in vitro LH pulse secretion and neural Kiss1 and Tac2 gene expression in female mice. (2020) Esparza, L.A., T. Terasaka, M.A. Lawson and A.S. Kauffman. Endocrinology, bqaa191, DOI: https://doi.org/10.1210/endocr/bqaa191

* Selected for the Endocrine Society Thematic Issue on Transgender Health and Medicine 2021.

Scientific societies fostering inclusivity through speaker diversity in annual meeting programming: a call to action. (2020) Segarra, V. A. C. Primus, G.A. Unguez, A.Edwards, C. Etson, S.C. Flores, C. Fry, A.N. Guillory, S. L. Ingram, M. Lawson, R. McGee, S. Paxson, L. Phelan, K. Suggs, L.R. Vega, E. Vuong, J.C. Havran, A. Leon, M.D. Burton, J.L. Lujan, M. Ramirez-Alvarado. Molecular Biology of the Cell, Nov 1;31(23):2495-2501. DOI: https://doi.org/10.1091/mbc.E20-06-0381

GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes . (2020) Nicholas, D.A., V.S. Knight, K.J. Tonsfeldt, T. Terasaka, O. Molinar-Inglis, S.B.Z. Stephens, J. Trejo, A.S. Kauffman, P.L. Mellon, and M.A. Lawson. (2020). Scientific Reports 10, 13063 (2020). DOI: https://doi.org/10.1038/s41598-020-69913-z

Scientific Societies Fostering Inclusive Scientific Environments through Travel Awards: Current Practices and Recommendations. (2020) Segarra, V.A. L.R. Vega, C. Primus, C. Etson, A.N. Guillory, A. Edwards, S.C. Flores, C. Fry, S.L. Ingram, M. Lawson, R. McGee, S. Paxson L. Phelan, K. Suggs E. Vuong, L. Hammonds-Odie, M. J. Leibowitz, MariaElena Zavala, J. L. Lujan, and M. Ramirez-Alvarado. CBE-Life Sciences Education 19 (2) es3 pp1-10. DOI: https://doi.org/10.1187/cbe.19-11-0262

SRXN1 is Necessary for Resolution of GnRH-Induced Oxidative Stress and Induction of Gonadotropin Gene Expression. Kim, T., D. Li, T. Terasaka, D. A. Nicholas, V.S. Knight, J. J. Yang, and M.A. Lawson. (2019) Endocrinology, 160 (11) pp. 2543-2555. DOI: https://doi.org/10.1210/en.2019-00283

The RNA-binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH. (2019) Terasaka, T., T. Kim, H. Dave; B. Gangapurkar, D.A. Nicholas, O, Munoz, E. Terasaka, D. Li, and M. A. Lawson. Endocrinology ,160 (8) pp.1999-2014. DOI: https://doi.org/10.1210/en.2019-00203 .

*Selected for commentary:
class="style11">ELAVL1 Elevates Insights: The Ups and Downs of Regulated mRNA Translation in the Control of Gonadotropin Release. (2019). A. M. MacNicol, A. Odle, and G. V. Childs, Endocrinology , 160 (10) pp. 2466–2468. DOI: https://doi.org/10.1210/en.2019-00524.

Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. (2019) Homer, M.V., T. Toloubeydokhti, M. A. Lawson, G. Garzo, A. J. Duleba, and R. J. Chang. (2019). Journal of the Endocrine Society, 3 (4), pp 687–698. DOI:

Induction of stress signaling in vitro and suppression of gonadotropin secretion by free fatty acids in female mouse gonadotropes. (2018) Li, S., E. F. Mbong, D. T. John, T. Terasaka, D. Li, and M. A. Lawson (2018)." Endocrinology 159 (2):1074-1087. DOI: https://doi.org/10.1210/en.2017-00638

*Selected for the Endocrine Society Thematic Issue on Neuroendocrinology 2019.

Reactive oxygen species link gonadotropin-releasing hormone receptor signaling cascades in the gonadotrope. (2017) Terasaka, T., M. E. Adakama , S. Li, T. Kim, E. Terasaka, D. Li, and M. A. Lawson (2017) Front. Endocrinol. 8:286. DOI: https://doi.org/10.3389/fendo.2017.00286

GnRH regulates gonadotropin gene expression through NADPH/Dual Oxidase-derived reactive oxygen species. (2015) Kim, T., and M. A. Lawson, (2015) Endocrinology 156 (6): 2185-2199. DOI: https://doi.org/10.1210/en.2014-1709

Lack of serum anti-Mullerian Hormone responses following recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome. (2015) Cook-Andersen, H., S. S. Chuan, K. Maas, M.A. Rosencrantz, H. I. Su, M. A. Lawson, H.D. Mason, and R. J. Chang. J. Clin. Endocrinol. Metab. 100 (1): 251–257. PDF DOI: https://doi.org/10.1210/jc.2014-2948

Regulation of protease-activated receptor-1 signaling by the adaptor protein complex-2 and R4 subfamily of regulator of G protein signaling proteins. (2014) Chen, B., D. P. Siderovski, R. R. Neubig, M. A. Lawson, and JoAnn Trejo. J. Biol. Chem. 289 (3): 1580-1591. PDF DOI: https://doi.org/10.1074/jbc.M113.528273

Translational control in the gonadotrope. (2014) T. Kim, M. T. Do, M. M. A. Lawson. Mol. Cell. Endocrinology. 385 (1-2): 78-87. PDF DOI: https://doi.org/10.1016/j.mce.2013.09.007

Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling. (2014) Do, M.T., T. Kim, F. He, H. Dave, U. A. Astorga, R. E. Intriago, S. Jain, and M. A. Lawson. Mol. Cell. Endocrinology. 382 (1):1346-1357. PDF DOI: https://doi.org/10.1016/j.mce.2013.10.007

Meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the pipeline. Lawson, M.(2013) Endocrinology 154 (8): 2581-2585. PDF DOI: https://doi.org/10.1210/en.2013-1421

Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation in GT1-7 cells. (2013) Terasaka, T., F. Otsuka, N. Tsukamoto, E. Nakamura, K. Inagaki, K. Toma, K. Ogura-Ochia, C. Glidewell-Kenney, M. A. Lawson, H. Makino. Mol. Cell. Endocrinol. 381 (1): 8-15. PDF DOI: https://doi.org/10.1016/j.mce.2013.07.009

hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. (2013) Park, S.-J., T.-S. Kim, C.-K. Park, S.-H. Lee, K.-S. Lee, I.-K. Lee, J.-W. Park, M. A. Lawson, and D-S. Lee. J. Mol. Endocrinol. 50 (2): 151-166. PDF DOI: https://doi.org/10.1016/j.mce.2011.08.001

Interaction between Gonadotropin-Releasing Hormone and Bone Morphogenetic Protein-6 and –7 Signaling in LβT2 Gonadotrope Cells. (2012) Takeda, M., F. Otsuka, H. Takahashi, K. Inagaki, T. Miyoshi, N. Tsukamoto, H. Makino, and M. A. Lawson Mol. Cell. Endocrinol. 348 (1): 146-154. PDF

Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-gene is mediated by differential expression of positive regulatory activator protein factors and co-repressors SKIL and TGIF1. (2011) Mistry, D S., R. Tsutsumi, M. Fernandez, S. Sharma, S. A. Cardenas, M. A. Lawson, and N. J. G. Webster. (2011). Mol. Endocrinol. 25 (8): 1387-1403. PDF

Modulation of GnRH-Induced ERK Activation by Dual Specificity Protein Phosphatase 1 in LβT2 Gonadotropes. (2010) Nguyen, K. A., R. E. Intriago, H. C. Upadhyay, S. J. Santos, N. J. G. Webster, and M. A. Lawson. Endocrinology 151 (10): 4882-4893. PDF

Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. (2010) Park, A. S. M. A. Lawson, S. S. Chuan, S. E. Oberfield, K. M. Hoeger, S. F. Witchell, and R. J. Chang. J. Clin. Endocrinol. Metab. 95 (4): 1786-1792. PDF

Regulation of gonadotropin-releasing hormone production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. (2009) Otani, H., F. Otsuka, M. Takeda, T. Mukai, T. Terasaka, T. Miyoshi, K. Inagaki, J. Suzuki, T. Ogura, M. A. Lawson, and H. Makino. J. Endocrinol. 203 (1): 87-97. PDF

Insulin augments gonadotropin releasing hormone induction of translation in LbetaT2 cells. (2009) Navratil, A. M., H. Song, J. B. Hernandez, B. D. Cherrington, S. J. Santos, J. M. Low, M. T. Do, and M. A. Lawson. Mol. Cell. Endocrinol. 311 (1-2): 47-54. PDF

GnRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. (2009) Do, M. T., S. Santos, and M. A. Lawson. Mol. Endocrinol. , 23 (1): 100-112. PDF

A proteomic comparison of immature and mature gonadotropes reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. (2008) Feng, J., M. A. Lawson, P. Melamed. Biol. Reprod. 79: 546–561. PDF

Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women . (2008) Lawson, M.A., S. Jain, S. Sun, K. Patel, P. J. Malcolm, R. J. Chang. (2008).J. Clin. Endocrinol. Metab, 93 (6): 2089-2096. PDF

Pulse sensitivity of the LHβ promoter is determined by a negative feedback loop involving Egr1 and Nab 1/2 .(2007) Lawson, M. A., R. Tsutsumi, H. Zhang, I. Talukadar, B. K. Butler, S. J. Santos, P. M. Mellon, and N. J. G. Webster.Mol. Endocrinol. , 21 (5):1175–1191. PDF

Activin modulates the transcriptional response of LβT2 cells to GnRH and alters cellular proliferation . (2006) Zhang, H., J. S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M. A. Lawson, P. L. Mellon and N. J. Webster. Mol. Endocrinol. 20 (11): 2909-2930. PDF

Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LβT2 . (2004) Nguyen, K. A., S. J. Santos, M. K. Kreidel, A. L. Diaz, R. Rey and M. A. Lawson.Mol. Endocrinol. 18 (5): 1301-1312. PDF

Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion . (2003) Patel, K., M. S. Coffler, M. H. Dahan, R. Y. Yoo, M. A. Lawson, P. J. Malcom and R. J. Chang.J. Clin. Endocrinol. Metab. 88 (11): 5456-5461. PDF

Different signaling pathways control acute induction versus long-term repression of LHβ transcription by GnRH . (2002) Vasilyev, V. V., M. A. Lawson, D. DiPaolo, N. J. G. Webster and P. L. Mellon.Endocrinology 143 (9): 3414-1426. PDF

Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat . (2002) Liu, S., K. M. Ogilvie, K. Klausing, M. A. Lawson, D. Jolley, D. Li, J. Bilakovics, B. Pascual, N. Hein, M. Urcan and M. D. Leibowitz. Endocrinology 143 (8): 2880-2885. PDF

Neuron-specific expression in vivo by defined transcription regulatory elements of the gonadotropin-releasing hormone gene . (2002)Lawson, M. A., L. A. MacConell, J. Kim, B. T. Powl, S. B. Nelson and P. L. Mellon. Endocrinology 143 (4): 1404-1412. PDF

GnRH gene expression: lessons learned from immortalized cells . (2002) Lawson, M. A. and P. L. Mellon. In: Neuroplasticity, development, and steroid hormone action. R.J. Handa (ed.)CRC Press, Boca Raton, LA. 141-151. PDF

Androgen responsiveness of the pituitary gonadotrope cell line LbetaT2. (2001) Lawson, M. A., D. Li, C. A. Glidewell-Kenney and F. J. Lopez.J. Endocrinol. 170 (3): 601-607. PDF

Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. (2000) Sosnowski, R., P. L. Mellon and M. A. Lawson. Mol. Endocrinol. 14 (11): 1811-1819. PDF

Regulation of the hypothalamic-pituitary-gonadal axis: role of gonadal steroids and implications for the menopause. (2000) Lopez, F. J., P. D. Finn, M.A. Lawson, and A. Negro-Vilar. In: Menopause. R. Lobo, R. Marcus, and J Kelsey. (eds.). Academic Press, San Diego. Academic Press, San Diego. 33-60. PDF

Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. (2000) Nelson, S. B., M. A. Lawson, C. G. Kelley and P. L. Mellon. Mol. Endocrinol. 14 (9): 1509-1522. PDF