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Department of Obstetrics, Gynecology & Reproductive Sciences OB/GYN
  1. Department of OBGYN & Reproductive Sciences
  2. Research
  3. Research Labs
  4. Kauffman Lab
  5. Publications

Kauffman Lab Publications

Full list of publications on PubMed

Featured Research Publications

Selected publications from the past 5 years (updated Fall 2024)

EA Coutinho, LA Esparza, PH Steffen, R Liaw, S Bolleddu, and AS Kauffman. Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice. FASEB Journal, 38:e70078. doi:10.1096/fj.202401696R. 2024.

AS Kauffman. Androgen inhibition of reproductive neuroendocrine function in females and transgender males. Endocrinology, 165(10): bqae113. doi: 10.1210/endocr/bqae113. 2024.

EA Coutinho*, LA* Esparza, J Rodriguez, J Yang, D Schafer, and AS Kauffman. Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome. Human Reproduction, deae153, https://doi.org/10.1093/humrep/deae153. 2024.

KM Hatcher, L Costanza, AS Kauffman, and SBZ Stephens. The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice. Frontiers in Endocrinology, 14: 1093592. 2023. [PMCID: PMC9951589]

EA Coutinho, LA Esparza, AD Hudson, N Rizo, P Steffen, and AS Kauffman. Conditional deletion of KOR (Oprk1) in kisspeptin cells does not alter LH pulses, puberty, or fertility in mice. Endocrinology, 163(12): bqac175. 2022. [PMCID: PMC10233252]

SJ Semaan and AS Kauffman. Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset. Mol. Cell. Endocrinology. Jul 1; 551:111654. doi: 10.1016/j.mce.2022.111654. 2022. [PMCID: PMC9889105]

AS Kauffman. Neuroendocrine mechanisms underlying estrogen positive feedback and the LH surge. Frontiers in Neuroscience, 16: 953252. doi.10.3389/fnins.2022.953252. 2022. [PMCID: PMC9364933]

AD Hudson and AS Kauffman. Metabolic actions of kisspeptin signaling: effects on body weight, energy expenditure, and feeding. Pharmacology & Therapeutics. 231: 107974, 1-14. 2022. [PMCID: PMC8884343]

MA Mohr, LA Esparza, P Steffen, PE Micevych, and AS Kauffman. Progesterone receptors in AVPV kisspeptin neurons are sufficient for positive feedback induction of the LH surge. Endocrinology, 162 (11) 1-8. bqab161. 2021. [PMCID: PMC8423423]

Stephens SBZ and AS Kauffman. Estrogen regulation of the molecular phenotype and active translatome of AVPV kisspeptin neurons. Endocrinology, 162 (9): bqab080. 2021. [PMCID: PMC8286094]

Esparza LA, T Terasaka, MA Lawson, and AS Kauffman. Androgen suppresses in vivo and in vitro LH pulse secretion and neural Kiss1 and Tac2 gene expression in female mice. Endocrinology, 161(12): bqaa191. 2020.​ ​[PMCID: PMC7671291] ​

D Nicholas, V Knight, K Tonsfeldt, T Terasaka, O Molinar-Inglis, S Stephens, J Trejo, AS Kauffman, PL Mellon, MA Lawson. GLUT1-mediated Glycolysis Supports GnRH-induced Secretion of Luteinizing Hormone from Female Gonadotropes. Scientific Reports, 10(1):13063. 2020. [ PMCID: PMC7400764]

Esparza LA, DA Schafer, BS Ho, VG Thackray, and AS Kauffman. Hyperactive LH pulses and elevated kisspeptin and NKB gene expression in the arcuate nucleus of a PCOS mouse model. Endocrinology, 161(4): 1-15, 2020. [PMCID: PMC7341557]

Tolson KP, N Marooki, JP De Bond, E Walenta, SBZ Stephens, RB Liaw, R Savur, A Wolfe, DY Oh, JT Smith, and AS Kauffman. Conditional knockout of kisspeptin signaling in brown adipose tissue increases metabolic rate and body temperature and lowers body weight. FASEB Journal, 34(1): 107-121. 2020. [PMCID: PMC7202476]

Tolson KP, N Marooki, A Wolfe, JT Smith, and AS Kauffman. Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype. Molecular and Cellular Endocrinology , 498: 110559. 2019. [PMCID: PMC6814569]

Stephens SBZ, N Di Giorgio, RB Liaw, RA Parra, JA Yang, N Chahal, VA Lux-Lantos, and AS Kauffman. Estradiol-dependent and -independent stimulation of Kiss1 expression in the amygdala, BNST, and lateral septum of mice. Endocrinology. 159: 3389-3402, 2018. [PMCID: PMC6112601]

Yang JA, JK Hughes, RA Parra, KM Volk, and AS Kauffman. Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice. Journal of Endocrinology, 239: 339-350, 2018. [PMCID: PMC6214202]